TLR4 antibody
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935106861
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name
TLR4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08727
tested applications
ELISA, WB, IHC
Description
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | toll-like receptor 4 (TLR4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:100 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 95 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O00206 |
| Gene ID | 7099 |
| Alias | Toll-like receptor 4,TOLL,CD284,TLR-4,ARMD10,hToll |
| Background | Antibody anti-TLR4 |
| Status | RUO |
| Note | Mol. Weight 95 kDa |
Descripción
Toll-like receptor 4 (TLR4) is a member of the toll-like receptor family of proteins, which play crucial roles in the innate immune system. TLR4 is well-known for its capacity to detect lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, which is a pathogen-associated molecular pattern (PAMP) that signals the presence of bacterial infections. Upon binding to LPS, TLR4 triggers a cascade of immune responses, including the activation of nuclear factor-kappa B (NF-κB) and the production of pro-inflammatory cytokines. These responses lead to a rapid immune reaction, making TLR4 essential for the early detection and management of bacterial infections. TLR4 is expressed in various cell types, including macrophages, dendritic cells, epithelial cells, and endothelial cells. The receptor is unique among TLRs due to its ability to signal through two distinct adaptor pathways: MyD88-dependent and TRIF-dependent pathways, which allows TLR4 to activate a broad array of immune responses. While critical in defense against infection, excessive or dysregulated TLR4 activation can contribute to chronic inflammation, autoimmune disorders, and septic shock, making TLR4 a target of interest for both enhancing and dampening immune responses therapeutically.
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