anti- Tie2 antibody
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935106861
info@markelab.com
name
anti- Tie2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08690
tested applications
ELISA, WB, IHC, IF
Description
This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | TEK tyrosine kinase, endothelial |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 126kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q02763 |
| Gene ID | 7010 |
| Alias | Angiopoietin-1 receptor,Endothelial tyrosine kinase,TIE2,VMCM,GLC3E,TIE-2,VMCM1,CD202B,Tyrosine-protein kinase receptor TEK,Tunica interna endothelial cell kinase |
| Background | Antibody anti-TEK |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
TEK, also known as TEK receptor tyrosine kinase (also termed Tie2 in some literature), is a receptor tyrosine kinase (RTK) with significant roles in vascular development, maintenance, and angiogenesis. Receptor tyrosine kinases are a class of cell surface receptors that, upon ligand binding, activate intracellular signaling cascades through phosphorylation. Specifically, the TEK/Tie2 receptor is primarily expressed in endothelial cells, which line blood vessels, as well as in certain subsets of hematopoietic cells. Its ligand, angiopoietin, specifically angiopoietins-1 and -2 (ANGPT1 and ANGPT2), modulates TEK signaling and plays essential roles in vessel stabilization, endothelial survival, and inflammatory responses. TEK signaling plays an essential role in regulating vascular quiescence and homeostasis. In developing and mature vasculature, TEK helps balance angiogenesis, where new blood vessels form from existing ones, with vascular stability and permeability. This function makes TEK a crucial player in several physiological and pathological processes, from wound healing to cancer and other angiogenesis-dependent diseases. Dysfunctional TEK signaling has been implicated in a range of vascular and inflammatory diseases, including tumor angiogenesis, diabetic retinopathy, and sepsis.
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