TFAM antibody
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935106861
info@markelab.com
name
TFAM antibody
category
Primary Antibodies
provider
FineTest
reference
FNab08615
tested applications
ELISA, WB, IHC, IP
Description
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | transcription factor A, mitochondrial (TFAM) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:3000; IP: 1:500-1:1000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 25 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q00059 |
| Gene ID | 7019 |
| Alias | Transcription factor A, mitochondrial (mtTFA),Mitochondrial transcription factor 1 (MtTF1),Transcription factor 6 (TCF-6),Transcription factor 6-like 2,TFAM,TCF6,TCF6L2 |
| Background | Antibody anti-TFAM |
| Status | RUO |
| Note | Mol. Weight 25 kDa |
Descripción
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TFAM antibody
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
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