SF3A1 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence(BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | splicing factor 3a, subunit 1, 120kDa (SF3A1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 120-130 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q15459 |
| Gene ID | 10291 |
| Alias | Splicing factor 3A subunit 1,SF3a120,Spliceosome-associated protein 114 (SAP 114),SF3A1,SAP114 |
| Background | Antibody anti-SF3A1 |
| Status | RUO |
| Note | Mol. Weight 120-130 kDa |
Descripción
Related Products
SF3A1 antibody
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence(BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
Ver Producto
Splicing Factor 3A Subunit 1 (SF3A1) Antibody
SF3A1 Antibody is a Rabbit Polyclonal antibody against SF3A1. This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.
Ver Producto
Splicing Factor 3A, Subunit 1, 120 kDa (SF3A1) Antibody
Splicing Factor 3A, Subunit 1, 120 kDa Antibody is a Rabbit Polyclonal antibody against Splicing Factor 3A, Subunit 1, 120 kDa.
Ver Producto