SERPINB6 antibody
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935106861
info@markelab.com
name
SERPINB6 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07747
tested applications
ELISA, WB, IHC
Description
May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood(By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | serpin peptidase inhibitor, clade B(ovalbumin), member 6 (SERPINB6) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 42 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P35237 |
| Gene ID | 5269 |
| Alias | CAP,PI6,PTI,PI-6,SPI3,DFNB91,MSTP057,Serpin B6,Cytoplasmic antiproteinase,Peptidase inhibitor 6,Placental thrombin inhibitor |
| Background | Antibody anti-SERPINB6 |
| Status | RUO |
| Note | Mol. Weight 42 kDa |
Descripción
SERPINB6, a member of the serpin (serine protease inhibitor) superfamily, is a protein that plays a crucial role in protecting cells from the damaging effects of proteolysis, particularly in the inner ear and other tissues where protease activity must be tightly regulated. Unlike other serpins that inhibit extracellular proteases, SERPINB6 primarily functions within cells to protect against intracellular proteases, including those released during stress or injury. This protein is encoded by the SERPINB6 gene located on chromosome 6p25.2. SERPINB6 has garnered significant interest due to its implications in auditory protection and various pathological conditions, including hearing loss and certain neurodegenerative diseases.
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