anti- SERPINA10 antibody

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935106861
info@markelab.com
name
anti- SERPINA10 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07740
tested applications
ELISA, WB, IHC, IF
Description
Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | serpin peptidase inhibitor, clade A(alpha-1 antiproteinase, antitrypsin), member 10 |
Host | Mouse |
Reactivity | human |
Recommended Dilution | WB: 1:1500-1:6000; IF: 1:50-1:500; IHC: 1:50-1:500 |
Clonality | monoclonal |
Conjugation | Unconjugated |
Isotype | IgG1 |
Clone ID | 4F10 |
Observed MW | 51 kDa |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Protein A+G purification |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, WB, IHC, IF |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | Q9UK55 |
Gene ID | 51156 |
Alias | PZI,ZPI,Protein Z-dependent protease inhibitor,Serpin A10,PZ-dependent protease inhibitor |
Background | Antibody anti-SERPINA10 |
Status | RUO |
Note | This product is for research use only. |
Descripción
SERPINA10 is a gene encoding the protein Z-dependent protease inhibitor (ZPI), which is a member of the serpin (serine protease inhibitor) superfamily. The SERPINA10 gene is located on chromosome 14q32.1 and plays a critical role in the regulation of coagulation, specifically by inhibiting factors involved in the blood clotting cascade. ZPI is unique among the serpin family members because its inhibitory activity is modulated by the presence of protein Z, a cofactor that enhances its ability to inhibit coagulation factors. The understanding of SERPINA10 is essential in the context of hemostasis and thrombosis, as abnormalities in its function can lead to a predisposition to thrombotic disorders.
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