SERPINA10 antibody
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935106861
info@markelab.com
name
SERPINA10 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07739
tested applications
ELISA, WB, IHC
Description
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (SERPINA10) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 51 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UK55 |
| Gene ID | 51156 |
| Alias | PZI,ZPI,Protein Z-dependent protease inhibitor,Serpin A10,PZ-dependent protease inhibitor |
| Background | Antibody anti-SERPINA10 |
| Status | RUO |
| Note | Mol. Weight 51 kDa |
Descripción
SERPINA10 is a gene encoding the protein Z-dependent protease inhibitor (ZPI), which is a member of the serpin (serine protease inhibitor) superfamily. The SERPINA10 gene is located on chromosome 14q32.1 and plays a critical role in the regulation of coagulation, specifically by inhibiting factors involved in the blood clotting cascade. ZPI is unique among the serpin family members because its inhibitory activity is modulated by the presence of protein Z, a cofactor that enhances its ability to inhibit coagulation factors. The understanding of SERPINA10 is essential in the context of hemostasis and thrombosis, as abnormalities in its function can lead to a predisposition to thrombotic disorders.
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