SELPLG antibody
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935106861
info@markelab.com
name
SELPLG antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09941
tested applications
ELISA, WB, IHC
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | P-selectin glycoprotein ligand 1 (SELPLG) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:20 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 120 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q14242 |
| Gene ID | 6404 |
| Alias | P-selectin glycoprotein ligand 1,CLA,CD162,PSGL1,PSGL-1,Selectin P ligand |
| Background | Antibody anti-SELPLG |
| Status | RUO |
| Note | Mol. Weight 120 kDa |
Selectin P ligand (SELPLG), also known as CD162 or P-selectin glycoprotein ligand-1 (PSGL-1), is a critical adhesion molecule that mediates interactions between leukocytes and endothelial cells. Encoded by the SELPLG gene on chromosome 12 in humans, SELPLG plays an essential role in the immune response by facilitating leukocyte tethering and rolling on the endothelium during inflammation and immune surveillance. This glycoprotein ligand interacts with selectins, specifically P-, E-, and L-selectins, which are expressed on activated endothelial cells and platelets, to initiate leukocyte adhesion at inflammation sites. SELPLG's ability to engage in interactions with multiple selectins allows it to participate in a variety of immune functions, from neutrophil recruitment to lymphocyte homing and trafficking. This glycoprotein ligand is particularly important in pathological conditions where leukocyte migration into tissues is crucial, such as infection, inflammation, and tissue injury.
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