RSPO3 antibody
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935106861
info@markelab.com
name
RSPO3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07512
tested applications
ELISA, WB, IHC
Description
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6(LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway(PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | R-spondin 3 homolog (RSPO3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:100-1:400 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 40 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9BXY4 |
| Gene ID | 84870 |
| Alias | R-spondin-3,Protein with TSP type-1 repeat (hPWTSR),Roof plate-specific spondin-3 (hRspo3),Thrombospondin type-1 domain-containing protein 2,RSPO3,PWTSR,THSD2 |
| Background | Antibody anti-RSPO3 |
| Status | RUO |
| Note | Mol. Weight 40 kDa |
Descripción
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