ROR1 antibody

Este producto es parte de ROR - receptor tyrosine kinase like orphan receptor
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935106861
info@markelab.com
name
ROR1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07386
tested applications
ELISA, WB, IHC

Description

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
receptor tyrosine kinase-like orphan receptor 1 (ROR1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
130-140 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q01973
Gene ID
4919
Alias
NTRKR1,dJ537F10.1,Inactive tyrosine-protein kinase transmembrane receptor ROR1,Neurotrophic tyrosine kinase, receptor-related 1
Background
Antibody anti-ROR1
Status
RUO
Note
Mol. Weight 130-140 kDa

Descripción

ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1) is a member of the receptor tyrosine kinase family, playing a pivotal role in embryonic development and cellular signaling. While minimally expressed in normal adult tissues, ROR1 is highly expressed in various cancers, including chronic lymphocytic leukemia and breast cancer, where it contributes to tumor progression, survival, and metastasis. This makes ROR1 a promising therapeutic target in oncology. The receptor participates in Wnt5a-mediated non-canonical Wnt signaling pathways, which regulate cell migration and cytoskeletal dynamics, critical processes during development and pathological states such as cancer. Its restricted expression pattern in normal tissues highlights its potential for targeted cancer therapies.

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