TNFSF11 antibody
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name
TNFSF11 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07108
tested applications
ELISA, WB, IHC, IF
Description
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | tumor necrosis factor (ligand) superfamily, member 11 (TNFSF11) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 32 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O14788 |
| Gene ID | 8600 |
| Alias | Tumor necrosis factor ligand superfamily member 11,ODF,OPGL,sOdf,CD254,OPTB2,RANKL,TNLG6B,TRANCE,hRANKL2,Osteoclast differentiation factor,Osteoprotegerin ligand,Receptor activator of nuclear factor kappa-B ligand, |
| Background | Antibody anti-TNFSF11 |
| Status | RUO |
| Note | Mol. Weight 32 kDa |
Descripción
TNFSF11, also known as RANKL (Receptor Activator of Nuclear Factor Kappa-Β Ligand), is a member of the tumor necrosis factor (TNF) superfamily. This protein is critical for bone metabolism, immune system regulation, and lymphoid tissue development. RANKL is primarily expressed on osteoblasts, T cells, and stromal cells, playing a major role in osteoclast differentiation and activation by binding to its receptor, RANK (Receptor Activator of Nuclear Factor Kappa-Β). Through the interaction between RANK and RANKL, this signaling pathway facilitates bone remodeling by controlling osteoclast-mediated bone resorption. RANKL is also vital in immune responses and is implicated in the formation of lymph nodes and mammary gland development. The physiological significance of TNFSF11 is underscored by its role in balancing bone formation and resorption. Disruptions in RANKL signaling can lead to metabolic bone disorders such as osteoporosis and osteopetrosis. RANKL is also an area of interest in cancer research, particularly in understanding bone metastasis in certain cancers, as well as autoimmune diseases where its role in immune regulation may contribute to chronic inflammation.
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