anti- RAB1B antibody

Este producto es parte de RAB - member RAS oncogene family
anti- RAB1B antibody

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935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-RAB1B

proveedor

FineTest

reference

FNab07001

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).


Background

RAB1B, member RAS oncogene family (RAB1B) is a GTPase closely related to RAB1A and shares many functional similarities in regulating intracellular transport and vesicular trafficking RAB1B is involved in the trafficking of proteins from the ER to the Golgi, as well as the maintenance of membrane integrity and the regulation of cell growth RAB1B helps coordinate the transport of vesicles carrying cargo such as lipids and enzymes, playing a vital role in processes like protein secretion and receptor recycling Like RAB1A, RAB1B is also involved in regulating the organization of the Golgi apparatus and facilitating communication between the ER and Golgi in secretory cells Dysregulation of RAB1B has been associated with cancer, where abnormal vesicular trafficking can promote tumor growth and metastasis Additionally, RAB1B has been implicated in certain viral infections, where it aids in the cellular entry and replication of viruses, further emphasizing its relevance in both cellular function and disease

Características del producto

category

Primary Antibodies


clonality

polyclonal


reactivity

human,mouse,rat


immunogen target

RAB1B, member RAS oncogene family


host

Rabbit


isotype

IgG


conjugation

Unconjugated


form

liquid


tested applications

ELISA, WB, IHC


observerd MW

22 kDa


purity

≥95% as determined by SDS-PAGE


purification

Immunogen affinity purified


recommended dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200


size 1

100µg


storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)


or code

RAB1B


alias

Ras-related protein Rab-1B


note

This product is for research use only.


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