RAB1B antibody
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935106861
info@markelab.com
name
RAB1B antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07001
tested applications
ELISA, WB, IHC
Description
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB1B, member RAS oncogene family (RAB1B) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 22 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9H0U4 |
| Gene ID | 81876 |
| Alias | Ras-related protein Rab-1B |
| Background | Antibody anti-RAB1B |
| Status | RUO |
| Note | Mol. Weight 22 kDa |
Descripción
RAB1B, member RAS oncogene family (RAB1B) is a GTPase closely related to RAB1A and shares many functional similarities in regulating intracellular transport and vesicular trafficking RAB1B is involved in the trafficking of proteins from the ER to the Golgi, as well as the maintenance of membrane integrity and the regulation of cell growth RAB1B helps coordinate the transport of vesicles carrying cargo such as lipids and enzymes, playing a vital role in processes like protein secretion and receptor recycling Like RAB1A, RAB1B is also involved in regulating the organization of the Golgi apparatus and facilitating communication between the ER and Golgi in secretory cells Dysregulation of RAB1B has been associated with cancer, where abnormal vesicular trafficking can promote tumor growth and metastasis Additionally, RAB1B has been implicated in certain viral infections, where it aids in the cellular entry and replication of viruses, further emphasizing its relevance in both cellular function and disease
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