PTPRZ1 antibody
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935106861
info@markelab.com
name
PTPRZ1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab06949
tested applications
ELISA, WB
Description
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 163-175 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P23471 |
| Gene ID | 5803 |
| Alias | PTPZ,HPTPZ,PTP18,PTPRZ,RPTPB,HPTPzeta,PTP-ZETA,RPTPbeta,phosphacan,R-PTP-zeta-2,Protein-tyrosine phosphatase receptor type Z polypeptide 1,Protein-tyrosine phosphatase receptor type Z polypeptide 2,Receptor-type tyrosine-protein phosphatase zeta |
| Background | Antibody anti-PTPRZ1 |
| Status | RUO |
| Note | Mol. Weight 163-175 kDa |
Descripción
PTPRZ1, also known as RPTPζ, is a receptor-type protein tyrosine phosphatase highly expressed in the central nervous system, particularly in glial cells and neurons. Structurally, PTPRZ1 consists of extracellular carbonic anhydrase-like and fibronectin type III domains, a single transmembrane domain, and two intracellular phosphatase domains. PTPRZ1 regulates cell proliferation, differentiation, and migration, particularly in the context of neural development and repair. It acts as a receptor for pleiotrophin and midkine, growth factors involved in neuroprotection and neural plasticity. PTPRZ1 is crucial for maintaining oligodendrocyte function and myelination in the CNS. Dysregulation or overexpression of PTPRZ1 is associated with glioblastomas, where it promotes cell migration and survival. It is also implicated in neuropsychiatric conditions such as schizophrenia due to its role in synaptic regulation and plasticity. PTPRZ1’s multifunctionality underscores its significance in neural development, repair, and tumor biology.
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