PSAP antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | prosaposin (PSAP) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 62 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P07602 |
| Gene ID | 5660 |
| Alias | Prosaposin,Proactivator polypeptide,Saposin-A Alternative names: Protein A,Saposin-B-Val,Saposin-B Alternative names: Cerebroside sulfate activator (CSAct),Dispersin,Sphingolipid activator protein 1 (SAP-1),Sulfatide/GM1 activator,Saposin-C Alternative names: A1 activator,Co-beta-glucosidase,Glucosylceramidase activator,Sphingolipid activator protein 2 (SAP-2),Saposin-D Alternative names: Component C,Protein C,PSAP,GLBA,SAP1 |
| Background | Antibody anti-PSAP |
| Status | RUO |
| Note | Mol. Weight 62 kDa |
Descripción
Related Products
Human PSAP (Prosaposin) ELISA Kit
Ver Producto
Mouse PSAP (Prosaposin) ELISA Kit
Ver Producto
PSAP antibody
This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Ver Producto