POLR3D antibody
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Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | polymerase(RNA) III(DNA directed) polypeptide D, 44kDa (POLR3D) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 44 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P05423 |
| Gene ID | 661 |
| Alias | DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4),DNA-directed RNA polymerase III subunit D,Protein BN51,RNA polymerase III 47 kDa subunit,RPC53 homolog,POLR3D,BN51,BN51T |
| Background | Antibody anti-POLR3D |
| Status | RUO |
| Note | Mol. Weight 44 kDa |
Descripción
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