NHERF4 antibody

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Description
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PDZ domain containing 3 (NHERF4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 54-60KD |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q86UT5 |
| Gene ID | 79849 |
| Alias | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (NHERF-4),Intestinal and kidney-enriched PDZ protein,Natrium-phosphate cotransporter IIa C-terminal-associated protein 2 (Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2),PDZ domain-containing protein 2,PDZ domain-containing protein 3,Sodium-hydrogen exchanger regulatory factor 4,NHERF4,IKEPP,PDZD3,PDZK2 |
| Background | Antibody anti-PDZD3 |
| Status | RUO |
| Note | Mol. Weight 54-60KD |
Descripción
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NHERF4 antibody
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions.
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PDZ Domain Containing 3 (PDZD3) Antibody
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).
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