NR3C2 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Receptor for both mineralocorticoids(MC) such as aldosterone and glucocorticoids(GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements(MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nuclear receptor subfamily 3, group C, member 2 (NR3C2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:500-1:1000 ; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 107 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P08235 |
| Gene ID | 4306 |
| Alias | MR,MCR,MLR,NR3C2VIT,Mineralocorticoid receptor |
| Background | Antibody anti-NR3C2 |
| Status | RUO |
| Note | Mol. Weight 107 kDa |
Descripción
Nuclear receptor subfamily 3 group C member 2 (NR3C2), also known as the mineralocorticoid receptor (MR), is a nuclear receptor that mediates the effects of mineralocorticoids, particularly aldosterone, which regulates salt and water balance, blood pressure, and electrolyte homeostasis NR3C2 is primarily expressed in the kidneys, heart, and brain, where it controls the reabsorption of sodium and water, influencing blood volume and pressure It functions by binding to aldosterone and translocating to the nucleus, where it regulates the expression of genes involved in electrolyte balance and fluid retention NR3C2 is essential for maintaining blood pressure and regulating the body's response to dehydration and salt imbalances Dysregulation of NR3C2 has been linked to various cardiovascular and renal disorders, including hypertension, heart failure, and kidney disease Overactivation of MR signaling can lead to fluid retention and hypertension, while decreased activity can result in conditions like hypoaldosteronism In addition, MR is a target for drugs such as mineralocorticoid antagonists, which are used to treat conditions like heart failure and hypertension
Related Products
NR3C2 antibody
Receptor for both mineralocorticoids(MC) such as aldosterone and glucocorticoids(GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements(MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
Ver Producto
Mineralocorticoid Receptor (NR3C2) Antibody
NR3C2 Antibody is a Rabbit Polyclonal antibody against NR3C2. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Ver Producto
Mineralocorticoid Receptor (NR3C2) Antibody
Mineralocorticoid Receptor Antibody is a Rabbit Polyclonal against Mineralocorticoid Receptor.
Ver Producto