NOTCH2 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
NOTCH2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab10843
Tested Applications
ELISA, WB, IHC
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Notch homolog 2 (NOTCH2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 110kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q04721 |
| Gene ID | 4853 |
| Alias | AGS2,HJCYS,hN2,notch receptor 2 |
| Background | Antibody anti-NOTCH2 |
| Status | RUO |
| Note | Mol. Weight 110 kDa |
Background
NOTCH2 is a key receptor in the Notch signaling pathway that regulates cell proliferation, differentiation, and tissue patterning during development. Ligand binding induces proteolytic cleavage, releasing the NOTCH2 intracellular domain (NICD), which activates transcription of target genes to control cell fate decisions. NOTCH2 is particularly critical for organogenesis, including kidney development, where it regulates nephron formation and podocyte differentiation. Dysregulation of NOTCH2 is linked to various pathologies, including Alagille syndrome, where mutations impair liver, heart, and kidney development. NOTCH2 also plays a role in cancer, where aberrant signaling promotes tumorigenesis, particularly in breast, pancreatic, and biliary tract cancers. Knockout models demonstrate defects in kidney morphogenesis, osteoclast development, and hematopoiesis, highlighting NOTCH2’s essential role in organ development, cellular differentiation, and disease progression.
Productos relacionados
Neurogenic Locus Notch Homolog Protein 2 (NOTCH2) Antibody
NOTCH2 Antibody is a Rabbit Polyclonal Antibody against NOTCH2.…
Ver producto
Neurogenic Locus Notch Homolog Protein 2 Cleaved-Asp1733 (NOTCH2 Cleaved-D1733) Antibody
Rabbit polyclonal antibody against Notch 2 protein. Immunogen region is Internal. Specificity is as follows for the reac…
Ver producto
Neurogenic Locus Notch Homolog Protein 2 Cleaved-Ala1734 (NOTCH2 Cleaved-A1734) Antibody
Rabbit polyclonal antibody against NOTCH2 protein. Immunogen region is Internal. Specificity is as follows for the react…
Ver producto