anti- NOTCH1 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain(NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone(SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile(sensory) cilia at the left-right organiser(LRO).The antibody is specific to NOTCH1. It can recognize the full length NOTCH1(270 kDa) and all the three cleaved NOTCH1 forms 110-120 kDa.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Notch homolog 1, translocation-associated(Drosophila) |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 270 kDa,120kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P46531 |
| Gene ID | 4851 |
| Alias | AOS5,AOVD1,TAN1,Hn1,Translocation-associated notch protein TAN-1,notch receptor 1 |
| Background | Antibody anti-NOTCH1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
NOTCH1 is a transmembrane receptor of the Notch signaling pathway, which regulates critical processes such as cell fate determination, proliferation, differentiation, and apoptosis during development and tissue homeostasis. Upon ligand binding (e.g., Jagged or Delta-like ligands), the NOTCH1 receptor undergoes proteolytic cleavage, releasing its intracellular domain (NICD). NICD translocates to the nucleus, activating transcription of target genes, including HES and HEY family members, to modulate cell behavior. Dysregulation of NOTCH1 contributes to various diseases, including cancers such as T-cell acute lymphoblastic leukemia (T-ALL), where activating mutations drive aberrant proliferation. In addition, NOTCH1 plays a role in cardiovascular development, neural differentiation, and immune system regulation. Knockout studies reveal embryonic lethality due to disrupted vascular development and neurogenesis, demonstrating its essential role in embryonic and adult tissue homeostasis, cellular differentiation, and oncogenesis.
Related Products
Human NOTCH1(Neurogenic locus notch homolog protein 1) ELISA Kit
Ver Producto
Mouse Notch-1(Neurogenic locus notch homolog protein 1) ELISA Kit
Ver Producto
anti- Notch1 antibody
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.
Ver Producto