anti- NMUR1 antibody
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935106861
info@markelab.com
name
anti- NMUR1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05772
tested applications
ELISA, WB, IHC
Description
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | neuromedin U receptor 1 |
| Host | Rabbit |
| Reactivity | human,mouse |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 47 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9HB89 |
| Gene ID | 10316 |
| Alias | NMUR1,FM-3,FM3,GPC-R,GPR66,NMU1R,SNORF62 |
| Background | Antibody anti-NMUR1 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
NMUR1 is a G protein-coupled receptor activated by neuromedin U (NMU), a neuropeptide involved in regulating appetite, energy homeostasis, and inflammation. NMUR1 is primarily expressed in peripheral tissues, including the gastrointestinal tract, lungs, and immune cells, where it mediates NMU’s effects on smooth muscle contraction, inflammation, and immune responses. Upon activation, NMUR1 couples to Gq/11 proteins, leading to phospholipase C (PLC) activation, calcium mobilization, and smooth muscle contraction. NMUR1 plays a role in regulating gut motility, bronchoconstriction, and inflammatory responses, particularly in allergic conditions such as asthma and inflammatory bowel disease (IBD). Dysregulation of NMUR1 signaling contributes to inflammatory and metabolic disorders, where it amplifies immune responses and modulates energy expenditure. NMUR1 antagonists are being investigated for their potential to treat inflammatory diseases, asthma, and obesity, as NMU signaling through NMUR1 influences inflammation, energy balance, and smooth muscle activity.
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