NCK2 antibody
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Name
NCK2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab05584
Tested Applications
ELISA, WB, IHC
Description
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | NCK adaptor protein 2 (NCK2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 43 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O43639 |
| Gene ID | 8440 |
| Alias | NCK2, GRB4, NCKbeta, NCK adaptor protein 2 |
| Background | Antibody anti-NCK2 |
| Status | RUO |
| Note | Mol. Weight 43 kDa |
Background
NCK2, also called Grb4, is a close homolog of NCK1 and functions as an adaptor protein linking receptor tyrosine kinases (RTKs) and cytoplasmic signaling molecules. It contains three SH3 domains and one SH2 domain, enabling it to interact with proteins involved in actin cytoskeletal regulation, cell adhesion, and migration. NCK2 mediates signaling pathways that regulate cell growth, differentiation, and survival, particularly through interactions with proteins like WASP, WAVE, and PAK kinases. It has specialized roles in embryonic development, angiogenesis, and neuronal growth. Dysregulation of NCK2 is implicated in cancer, where it promotes migration and invasion through actin remodeling. Knockout models show impaired embryonic development, angiogenesis defects, and abnormalities in cell motility, underscoring its critical role in cytoskeletal dynamics and signal transduction.
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