CDH2 antibody
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935106861
info@markelab.com
name
CDH2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05571
tested applications
ELISA, IHC, WB
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density(By similarity).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | cadherin 2, type 1, N-cadherin(neuronal) (CDH2) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:1000-1:10000; IHC: 1:20-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | 1G1 |
| Observed MW | 130 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P19022 |
| Gene ID | 1000 |
| Alias | Cadherin-2,CDHN,NCAD,ACOGS,ADHD8,CD325,ARVD14,CDw325,Neural cadherin,N-cadherin |
| Background | Antibody anti-CDH2 |
| Status | RUO |
| Note | Mol. Weight 130 kDa |
Descripción
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This gene encodes a classical cadherin and member of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein is proteolytically processed to generate a calcium-dependent cell adhesion molecule and glycoprotein. This protein plays a role in the establishment of left-right asymmetry, development of the nervous system and the formation of cartilage and bone.
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