MYO7A antibody
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Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial(RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity(By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | myosin VIIA (MYO7A) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 160-255kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13402 |
| Gene ID | 4647 |
| Alias | DFNB2,MYU7A,NSRD2,USH1B,DFNA11,MYOVIIA,Unconventional myosin-VIIa |
| Background | Antibody anti-MYO7A |
| Status | RUO |
| Note | Mol. Weight 160-255 kDa |
Descripción
Myosin VIIA (MYO7A) is a motor protein that belongs to the myosin family, which converts chemical energy from ATP hydrolysis into mechanical work, enabling cellular movement MYO7A is essential for cellular processes such as vesicular trafficking, cell adhesion, and the transport of organelles It is particularly important in the sensory cells of the inner ear, where it plays a critical role in the function of hair cells responsible for hearing and balance MYO7A’s function is also crucial in the retina, where it helps transport proteins and other cellular components to the outer segments of photoreceptor cells Defects in MYO7A are associated with Usher syndrome type 1, a genetic disorder that causes congenital deafness and progressive blindness due to defects in the inner ear and retina MYO7A also plays a role in maintaining the structure of the photoreceptors and inner ear cells, making it an important protein for both sensory function and cellular transport in specialized cells of the sensory organs
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Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial(RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity(By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
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