anti- MYLK3 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
anti- MYLK3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05495
tested applications
ELISA, WB, IHC
Description
Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility(By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | myosin light chain kinase 3 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 85-100kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q32MK0 |
| Gene ID | 91807 |
| Alias | MLCK,MLCK2,caMLCK,Cardiac-MyBP-C-associated Ca/CaM kinase,Cardiac-MLCK |
| Background | Antibody anti-MYLK3 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Myosin light chain kinase 3 (MYLK3) is primarily expressed in cardiac muscle, where it plays a pivotal role in modulating heart muscle contraction and relaxation. Similar to MYLK2, MYLK3 phosphorylates the regulatory light chains of myosin II, facilitating efficient cross-bridge cycling and force production during cardiac cycles. MYLK3's activity is also dependent on calcium-calmodulin signaling, linking it to the intracellular calcium fluxes that drive cardiac contractility. MYLK3 is essential for maintaining myocardial function and is implicated in cardiac hypertrophy and heart failure when dysregulated. Emerging research highlights MYLK3's involvement in sarcomere organization and its potential as a therapeutic target for improving cardiac performance in disease settings. Together, MYLK2 and MYLK3 underscore the critical and tissue-specific roles of myosin light chain kinases in muscle physiology.
Related Products
anti- MYLK3 antibody
Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility(By similarity).
Ver Producto
Myosin Light Chain Kinase 3 (MYLK3) Antibody
MYLK3 Antibody is a Rabbit Polyclonal antibody against MYLK3. Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008.
Ver Producto
Mouse Myosin Light Chain Kinase 3 (MYLK3) Protein
Mouse Myosin Light Chain Kinase 3 (MYLK3) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).
Ver Producto