MYH9 antibody
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935106861
info@markelab.com
name
MYH9 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05480
tested applications
ELISA, WB, IHC, IF
Description
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation(in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | myosin, heavy polypeptide 9, non-muscle (MYH9) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB : 1:500-1:2000; IHC : 1:20-1:200; IF : 1:50-1:500 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 224 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P35579 |
| Gene ID | 4627 |
| Alias | Myosin-9,Cellular myosin heavy chain, type A,Myosin heavy chain 9,Myosin heavy chain, non-muscle IIa,Non-muscle myosin heavy chain A (NMMHC-A),Non-muscle myosin heavy chain IIa (NMMHC II-a, NMMHC-IIA),MYH9 |
| Background | Antibody anti-MYH9 |
| Status | RUO |
| Note | Mol. Weight 224 kDa |
Descripción
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MYH9 antibody
This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness.
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