MYBPC1 antibody
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Name
MYBPC1 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab05454
Tested Applications
ELISA, WB, IHC
Description
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | myosin binding protein C, slow type (MYBPC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 135-140kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q00872 |
| Gene ID | 4604 |
| Alias | LCCS4,CMYP16,MYBPCC,MYBPCS,MYOTREM,ssMyBP-C,Slow MyBP-C,C-protein skeletal muscle slow isoform |
| Background | Antibody anti-MYBPC1 |
| Status | RUO |
| Note | Mol. Weight 135-140 kDa |
Background
MYBPC1 is a structural protein predominantly expressed in slow-twitch skeletal muscles, where it plays a critical role in maintaining the structural integrity of sarcomeres and regulating muscle contraction. By interacting with myosin and actin filaments, it modulates their binding interactions and stabilizes the thick filaments within the muscle fibers. This ensures the proper alignment and function of the contractile apparatus. Mutations in MYBPC1 have been associated with various myopathies, including those characterized by muscle weakness and reduced contractility, particularly in conditions affecting slow-twitch muscles. These mutations can lead to disruptions in sarcomere assembly and force transmission. MYBPC1’s role in muscle biomechanics makes it an important focus of research into muscle function and disease mechanisms.
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