Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
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935106861
info@markelab.com
Precio
387.5€ (200 µl)
Antibody anti-AMHR2
proveedor
Abbexareference
abx432323Tested Applications
P-ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
AMHR2 Antibody is a Goat Polyclonal antibody against AMHR2.
Background
The anti-Müllerian hormone type-2 receptor (AMHR2) is a transmembrane serine/threonine kinase receptor crucial in reproductive system development and function. AMHR2 is expressed primarily in the gonads, particularly in Sertoli cells in males and granulosa cells in females, where it mediates the effects of anti-Müllerian hormone (AMH). During male embryogenesis, AMHR2 plays a pivotal role in the regression of the Müllerian ducts, structures that would otherwise develop into female reproductive organs, ensuring proper male reproductive tract formation. In females, AMHR2 is involved in ovarian folliculogenesis, regulating the sensitivity of granulosa cells to FSH (follicle-stimulating hormone), and is considered a marker of ovarian reserve. Mutations in the AMHR2 gene have been associated with disorders of sexual development, such as persistent Müllerian duct syndrome (PMDS) in males. AMHR2 also holds therapeutic potential as a target in the treatment of ovarian cancer, where its expression is often aberrantly regulated, and in fertility assessment due to its role in ovarian function. Its role in reproductive biology underscores its importance in both clinical and developmental contexts.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Anti-Mullerian Hormone Receptor Type 2 (AMHR2)
host
Goat
conjugation
Unconjugated
form
Liquid
tested applications
P-ELISA, WB
purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
size 1
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
AMHR2
dry ice
No
availability
Shipped within 1-3 working days.
alias
AMHR2,AMHR,MISR2
NCBI accession
NP_065434.1, NP_001158162.1, NP_001158163.1
note
This product is for research use only.
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