Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody

Este producto es parte de AMHR2 - Anti-Muellerian hormone type-2 receptor
Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody

Pida mas información

935106861

info@markelab.com

Precio

387.5€ (200 µl)

Antibody anti-AMHR2

proveedor

Abbexa

reference

abx432323

Tested Applications

P-ELISA, WB

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

AMHR2 Antibody is a Goat Polyclonal antibody against AMHR2.


Background

The anti-Müllerian hormone type-2 receptor (AMHR2) is a transmembrane serine/threonine kinase receptor crucial in reproductive system development and function. AMHR2 is expressed primarily in the gonads, particularly in Sertoli cells in males and granulosa cells in females, where it mediates the effects of anti-Müllerian hormone (AMH). During male embryogenesis, AMHR2 plays a pivotal role in the regression of the Müllerian ducts, structures that would otherwise develop into female reproductive organs, ensuring proper male reproductive tract formation. In females, AMHR2 is involved in ovarian folliculogenesis, regulating the sensitivity of granulosa cells to FSH (follicle-stimulating hormone), and is considered a marker of ovarian reserve. Mutations in the AMHR2 gene have been associated with disorders of sexual development, such as persistent Müllerian duct syndrome (PMDS) in males. AMHR2 also holds therapeutic potential as a target in the treatment of ovarian cancer, where its expression is often aberrantly regulated, and in fertility assessment due to its role in ovarian function. Its role in reproductive biology underscores its importance in both clinical and developmental contexts.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Anti-Mullerian Hormone Receptor Type 2 (AMHR2)


host

Goat


conjugation

Unconjugated


form

Liquid


tested applications

P-ELISA, WB


purification

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.


buffer

Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.


size 1

200 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

AMHR2


dry ice

No


availability

Shipped within 1-3 working days.


alias

AMHR2,AMHR,MISR2


NCBI accession

NP_065434.1, NP_001158162.1, NP_001158163.1


note

This product is for research use only.


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