Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
442€ (200 µl)
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935106861
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name
Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432322
tested applications
P-ELISA, WB
Description
AMHR2 Antibody is a Goat Polyclonal antibody against AMHR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Anti-Mullerian Hormone Receptor Type 2 (AMHR2) Immunogen: abx617280 - Internal region: HPQESHPFPESCPR |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 269 |
| NCBI Accession | NP_065434.1, NP_001158163.1 |
| Alias | AMHR2,AMHR,MISR2 |
| Background | Antibody anti-AMHR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The anti-Müllerian hormone type-2 receptor (AMHR2) is a transmembrane serine/threonine kinase receptor crucial in reproductive system development and function. AMHR2 is expressed primarily in the gonads, particularly in Sertoli cells in males and granulosa cells in females, where it mediates the effects of anti-Müllerian hormone (AMH). During male embryogenesis, AMHR2 plays a pivotal role in the regression of the Müllerian ducts, structures that would otherwise develop into female reproductive organs, ensuring proper male reproductive tract formation. In females, AMHR2 is involved in ovarian folliculogenesis, regulating the sensitivity of granulosa cells to FSH (follicle-stimulating hormone), and is considered a marker of ovarian reserve. Mutations in the AMHR2 gene have been associated with disorders of sexual development, such as persistent Müllerian duct syndrome (PMDS) in males. AMHR2 also holds therapeutic potential as a target in the treatment of ovarian cancer, where its expression is often aberrantly regulated, and in fertility assessment due to its role in ovarian function. Its role in reproductive biology underscores its importance in both clinical and developmental contexts.
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