Muellerian-Inhibiting Factor (AMH) Antibody
292.5€ (50 µl)
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935106861
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name
Muellerian-Inhibiting Factor (AMH) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034580
tested applications
ELISA, WB, IHC, FCM
Description
Anti Muellerian-Inhibiting Factor (AMH) is a member of the TGF beta superfamily. It is secreted as a homodimeric 140kD disulphide linked precursor that is cleaved to release the mature 30kD homodimer. Originally classified as a foetal testicular hormone that inhibits Anti-Mullerian duct development, AMH is expressed post natally by immature Sertoli cells, and to a lesser degree by granulosa cells. AMH plays a role in testicular differentiation and in the regulation of ovarian follicle growth.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Muellerian-Inhibiting Factor (AMH) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/2000, IHC-P: 1/25, FCM: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 50 µl |
| Size 2 | 200 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P03971 |
| NCBI Accession | NP_000470.2 |
| Alias | AMH,MIF |
| Background | Antibody anti-AMH |
| Status | RUO |
Descripción
Anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting factor (MIF), is a protein hormone that plays a critical role in the development of the reproductive system, particularly in males. It is produced by cells within the testes called Sertoli cells, as well as by granulosa cells in the ovaries of females. During fetal development in males, AMH is secreted by the Sertoli cells and functions to inhibit the development of the Müllerian ducts, which are precursor structures for female reproductive organs such as the fallopian tubes, uterus, and upper vagina. By suppressing the development of these Müllerian structures, AMH helps promote the formation of male reproductive organs, including the epididymis, vas deferens, and seminal vesicles. In females, AMH is also produced by granulosa cells within ovarian follicles, but its role is different. In females, AMH levels are highest during early follicular development and decline as follicles mature. AMH is involved in regulating the growth and development of ovarian follicles and has been used as a marker of ovarian reserve, which refers to the number and quality of a woman's remaining eggs
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