MMP14 antibody
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Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | matrix metallopeptidase 14 (membrane-inserted) (MMP14) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 65 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P50281 |
| Gene ID | 4323 |
| Alias | MMP-14,MMP-X1,MT-MMP,MT1MMP,MTMMP1,WNCHRS,MT1-MMP,MT-MMP 1,Membrane-type matrix metalloproteinase 1,Membrane-type-1 matrix metalloproteinase |
| Background | Antibody anti-MMP14 |
| Status | RUO |
| Note | Mol. Weight 65 kDa |
Descripción
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