MMP12 antibody
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935106861
info@markelab.com
name
MMP12 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab05234
tested applications
ELISA, WB, IHC, IF
Description
MMP12(Matrix metalloproteinase-12) is a 54 kDa proenzyme that is processed into a 45 kDa and then a 22 kDa active form(15723202). MMP9 and MMP12 promote intimal thickening by independent cleavage of N-cadherin, which elevates vascular smooth muscle cell proliferation via beta-catenin signalling. Its overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis(PMID: 21378275).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | matrix metallopeptidase 12(macrophage elastase) (MMP12) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 54 kDa, 45 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P39900 |
| Gene ID | 4321 |
| Alias | ME,HME,MME,MMP-12,Macrophage metalloelastase,Macrophage elastase |
| Background | Antibody anti-MMP12 |
| Status | RUO |
| Note | Mol. Weight 54 kDa, 45 kDa |
Descripción
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