LAMP2 antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
LAMP2 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab04686
Tested Applications
ELISA, WB, IHC, IF, FC
Description
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface(plasma membrane), and inter-and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | lysosomal-associated membrane protein 2 (LAMP2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 110-130kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P13473 |
| Gene ID | 3920 |
| Alias | CD107b,DND,LAMP-2,LAMPB,LGP-96,LGP110 |
| Background | Antibody anti-LAMP2 |
| Status | RUO |
| Note | Mol. Weight 110-130 kDa |
Background
Lysosome-associated membrane glycoprotein 2 (LAMP2) is a critical lysosomal membrane protein involved in autophagy, lysosomal biogenesis, and cellular homeostasis LAMP2 facilitates the fusion of autophagosomes with lysosomes, enabling the degradation of cellular components during autophagy LAMP2 exists in three isoforms (LAMP2A, LAMP2B, and LAMP2C), each with distinct roles in lysosome function LAMP2A is essential for chaperone-mediated autophagy (CMA), where it mediates the selective degradation of cytosolic proteins LAMP2B is primarily involved in macroautophagy, particularly in muscle and neuronal tissues Mutations in LAMP2 cause Danon disease, a rare lysosomal storage disorder characterized by cardiomyopathy, myopathy, and intellectual disability LAMP2 dysregulation has been linked to neurodegenerative diseases and cancers, where impaired autophagy disrupts cellular homeostasis and promotes disease progression LAMP2 also plays a role in immune responses, contributing to antigen processing and lysosomal exocytosis Its importance in autophagy, cellular stress responses, and disease underscores its critical role in maintaining cellular integrity
Productos relacionados
Lysosomal Associated Membrane Protein 2 (LAMP2) Antibody
LAMP2 Antibody is a Rabbit Polyclonal antibody against LAMP2. Lysosomal-associated membrane protein 2 (LAMP2, synonyms: …
Ver producto
Lysosomal Associated Membrane Protein 2 (LAMP2) Antibody
This product is currently in development. The lead time for this product may be several months. Please contact us at…
Ver producto
Lysosomal Associated Membrane Protein 2 (LAMP2) Antibody
Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenanc…
Ver producto