anti- JAML antibody
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Description
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adhesion molecule, interacts with CXADR antigen 1 |
| Host | Rabbit |
| Reactivity | human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 30kd,44kd,50-60kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q86YT9 |
| Gene ID | 120425 |
| Alias | AMICA,Gm638,AMICA1,CREA7-1,CREA7-4,Dendritic cell-specific protein,Adhesion molecule interacting with CXADR antigen 1 |
| Background | Antibody anti-JAML |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
Junctional adhesion molecule-like (JAML) protein is part of the immunoglobulin superfamily, which encompasses a wide range of proteins involved in cell-cell adhesion, immune responses, and cellular signaling. JAML is known for its critical role in the immune system, particularly in the regulation of immune cell interactions and functions. The protein is expressed predominantly on epithelial cells and various immune cells, including neutrophils and certain T-cell subsets, where it contributes to immune surveillance and tissue homeostasis.
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anti- JAML antibody
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.
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