IL5RA antibody
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Name
IL5RA antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab04280
Tested Applications
ELISA, WB, IHC
Description
This is the receptor for interleukin-5. The alpha chain binds to IL5.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | interleukin 5 receptor, alpha (IL5RA) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 43kd and 75kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q01344 |
| Gene ID | 3568 |
| Alias | IL5R,CD125,CDw125,HSIL5R3,IL-5 receptor subunit alpha,IL-5R subunit alpha,IL-5R-alpha,IL-5RA |
| Background | Antibody anti-IL5RA |
| Status | RUO |
| Note | Mol. Weight 43 kDa and 75 kDa |
Background
Interleukin-5 receptor subunit alpha (IL5RA) is a protein critical for mediating immune responses involving eosinophils. Encoded by the IL5RA gene, this receptor forms a part of the IL-5 receptor complex, which is primarily responsible for binding interleukin-5 (IL-5), a cytokine crucial in regulating the growth, differentiation, and activation of eosinophils and basophils. Eosinophils, in particular, are involved in immune responses against parasitic infections and play a role in allergic inflammation and diseases such as asthma and eosinophilic esophagitis. IL-5, along with its receptor IL5RA, is also implicated in the development and maintenance of T-helper 2 (Th2)-mediated immune responses, which play a role in allergic diseases. By engaging IL5RA on eosinophils and other cells, IL-5 signaling promotes survival, activation, and accumulation of these cells at inflammatory sites. Due to its central role in driving eosinophil-mediated inflammation, IL5RA is a target for therapeutic interventions, especially in asthma, chronic rhinosinusitis with nasal polyps, and hypereosinophilic syndrome.
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