IL2RG antibody

Este producto es parte de IL2RG - interleukin 2 receptor subunit gamma
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935106861
info@markelab.com
name
IL2RG antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04267
tested applications
ELISA, WB, FC

Description

Common subunit for the receptors for a variety of interleukins.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
interleukin 2 receptor, gamma(severe combined immunodeficiency) (IL2RG)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
42kd
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, FC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P31785
Gene ID
3561
Alias
Cytokine receptor common subunit gamma,P64,CIDX,IMD4,CD132,SCIDX,IL-2RG,SCIDX1,IL-2 receptor subunit gamma,IL-2R subunit gamma
Background
Antibody anti-IL2RG
Status
RUO
Note
Mol. Weight 42 kDa

Descripción

The Interleukin 2 Receptor Subunit Gamma (IL2RG), also known as the common gamma chain or γc, is a crucial component of several cytokine receptor complexes, specifically those for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Each of these cytokines plays a vital role in immune cell development, activation, and homeostasis. Because IL2RG is part of multiple cytokine receptor systems, it is often referred to as a "common" subunit, essential for the signaling functionality of these cytokines. The expression of IL2RG is indispensable for immune competence, influencing processes in adaptive immunity and innate immune responses. In its absence, severe immunodeficiency conditions, such as X-linked severe combined immunodeficiency (X-SCID), can occur, indicating its role in T cell, B cell, and natural killer (NK) cell development. IL2RG does not directly bind to cytokines but facilitates signal transduction by forming a complex with cytokine-specific receptor subunits and initiating intracellular signaling cascades. The signaling through IL2RG activates critical pathways, including JAK/STAT, MAPK, and PI3K/AKT, which are integral to immune cell differentiation, proliferation, and survival. Due to the centrality of IL2RG in immune system function, mutations in this gene have severe implications for immune cell functionality and host defense.

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