IL15RA antibody
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935106861
info@markelab.com
name
IL15RA antibody
category
Primary Antibodies
provider
FineTest
reference
FNab04222
tested applications
ELISA, WB, IHC
Description
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves SYK.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | interleukin 15 receptor, alpha (IL15RA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55-65 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13261 |
| Gene ID | 3601 |
| Alias | IL-15 receptor subunit alpha,CD215,IL-15R-alpha |
| Background | Antibody anti-IL15RA |
| Status | RUO |
| Note | Mol. Weight 55-65 kDa |
Descripción
Interleukin-15 receptor subunit alpha (IL15RA) is a receptor that binds to the cytokine interleukin-15 (IL-15), a protein central to immune system regulation, particularly in the development, activation, and survival of natural killer (NK) cells and memory CD8+ T cells. IL-15 plays a significant role in the immune response against viral infections and tumors and in sustaining long-lived immune memory. Unlike many other cytokine receptors, IL15RA binds IL-15 with very high affinity even without the presence of other receptor subunits, making it essential for IL-15’s function. This interaction is critical in immune homeostasis and is relevant in inflammation, cancer immunology, and autoimmune disease contexts.
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