FZD3 antibody
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935106861
info@markelab.com
name
FZD3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab10446
tested applications
ELISA, WB
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Frizzled-3 (FZD3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 76-130 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9NPG1 |
| Alias | FZD3,Fz3,frizzled 3,frizzled family receptor 3,Fz-3 |
| Background | Antibody anti-FZD3 |
| Status | RUO |
| Note | Mol. Weight 76-130 kDa |
FZD3 is a member of the Frizzled family involved primarily in non-canonical Wnt signaling pathways, including planar cell polarity (PCP) and Wnt/Ca2+ signaling. It is highly expressed in the nervous system, particularly during embryonic development, where it regulates axon guidance, neural crest cell migration, and synapse formation. FZD3 is critical for establishing cellular polarity, neural connectivity, and patterning during brain and spinal cord development. In the peripheral nervous system, it directs the migration of neural crest-derived cells and the growth of sensory and motor neurons. Dysregulation of FZD3 has been linked to neurodevelopmental disorders, such as defective axonal outgrowth and neuronal wiring defects. In cancer, FZD3 is implicated in promoting cell migration, invasion, and metastasis in certain cancers, including breast and colorectal cancers, through its role in non-canonical signaling. FZD3’s contribution to axonal regeneration and neural plasticity makes it a potential target for treating neurological injuries and neurodegenerative diseases. Overall, FZD3 is essential for neural development, cellular polarity, and migration, balancing normal development with disease pathology.
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