FUT4 antibody

Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
FUT4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab03248
tested applications
ELISA
Description
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | fucosyltransferase 4(alpha(1,3) fucosyltransferase, myeloid-specific) (FUT4) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | 0 |
Clonality | polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Observed MW | 95-110 kDa |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Immunogen affinity purified |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | P22083 |
Gene ID | 2526 |
Alias | LeX,CD15,ELFT,FCT3A,FUTIV,SSEA-1,FUC-TIV,Alpha-(1,3)-fucosyltransferase 4,Fucosyltransferase 4,Galactoside 3-L-fucosyltransferase |
Background | Antibody anti-FUT4 |
Status | RUO |
Note | Mol. Weight 95-110 kDa |
Descripción
FUT4 (fucosyltransferase 4) is a crucial enzyme in the glycosylation process, specifically responsible for catalyzing the transfer of fucose, a hexose sugar, to target glycoproteins and glycolipids. This process is essential in forming fucosylated glycans, such as the Lewis antigens. FUT4 belongs to the broader family of fucosyltransferases, enzymes that facilitate the addition of fucose residues to various substrates. These glycosylation modifications are important for many cellular functions, including cell adhesion, signal transduction, immune response, and development. One of the primary roles of FUT4 is in the synthesis of Lewis X antigen (CD15), a fucosylated oligosaccharide that plays a critical role in mediating cell-cell interactions. FUT4 is encoded by the FUT4 gene, which is located on chromosome 11q21-22 in humans. It is expressed in a variety of tissues but is especially prominent in the bone marrow, placenta, and immune cells. The enzyme's activity has been linked to processes such as leukocyte trafficking, inflammation, and tumor metastasis, due to its ability to regulate the presentation of fucosylated antigens on the cell surface.
Related Products

APC Anti-Human CD15(HI98)
Ver Producto
FITC Anti-Human CD15(HI98)
Ver Producto
FUT4 antibody
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.
Ver Producto