FUT4 antibody

Product specifications

Primary Antibodies

fucosyltransferase 4(alpha(1,3) fucosyltransferase, myeloid-specific) (FUT4)

Rabbit

Human

0

polyclonal

Unconjugated

IgG

95-110 kDa

≥95% as determined by SDS-PAGE

Immunogen affinity purified

100µg

liquid

ELISA

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

P22083

2526

LeX,CD15,ELFT,FCT3A,FUTIV,SSEA-1,FUC-TIV,Alpha-(1,3)-fucosyltransferase 4,Fucosyltransferase 4,Galactoside 3-L-fucosyltransferase

Antibody anti-FUT4

RUO

Mol. Weight 95-110 kDa

Descripción

FUT4 (fucosyltransferase 4) is a crucial enzyme in the glycosylation process, specifically responsible for catalyzing the transfer of fucose, a hexose sugar, to target glycoproteins and glycolipids. This process is essential in forming fucosylated glycans, such as the Lewis antigens. FUT4 belongs to the broader family of fucosyltransferases, enzymes that facilitate the addition of fucose residues to various substrates. These glycosylation modifications are important for many cellular functions, including cell adhesion, signal transduction, immune response, and development. One of the primary roles of FUT4 is in the synthesis of Lewis X antigen (CD15), a fucosylated oligosaccharide that plays a critical role in mediating cell-cell interactions. FUT4 is encoded by the FUT4 gene, which is located on chromosome 11q21-22 in humans. It is expressed in a variety of tissues but is especially prominent in the bone marrow, placenta, and immune cells. The enzyme's activity has been linked to processes such as leukocyte trafficking, inflammation, and tumor metastasis, due to its ability to regulate the presentation of fucosylated antigens on the cell surface.

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FUT4 antibody

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

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