FUT4 antibody

Este producto es parte de FUT4 - fucosyltransferase 4
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935106861
info@markelab.com
name
FUT4 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab03248
tested applications
ELISA

Description

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
fucosyltransferase 4(alpha(1,3) fucosyltransferase, myeloid-specific) (FUT4)
Host
Rabbit
Reactivity
Human
Recommended Dilution
0
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
95-110 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P22083
Gene ID
2526
Alias
LeX,CD15,ELFT,FCT3A,FUTIV,SSEA-1,FUC-TIV,Alpha-(1,3)-fucosyltransferase 4,Fucosyltransferase 4,Galactoside 3-L-fucosyltransferase
Background
Antibody anti-FUT4
Status
RUO
Note
Mol. Weight 95-110 kDa

Descripción

FUT4 (fucosyltransferase 4) is a crucial enzyme in the glycosylation process, specifically responsible for catalyzing the transfer of fucose, a hexose sugar, to target glycoproteins and glycolipids. This process is essential in forming fucosylated glycans, such as the Lewis antigens. FUT4 belongs to the broader family of fucosyltransferases, enzymes that facilitate the addition of fucose residues to various substrates. These glycosylation modifications are important for many cellular functions, including cell adhesion, signal transduction, immune response, and development. One of the primary roles of FUT4 is in the synthesis of Lewis X antigen (CD15), a fucosylated oligosaccharide that plays a critical role in mediating cell-cell interactions. FUT4 is encoded by the FUT4 gene, which is located on chromosome 11q21-22 in humans. It is expressed in a variety of tissues but is especially prominent in the bone marrow, placenta, and immune cells. The enzyme's activity has been linked to processes such as leukocyte trafficking, inflammation, and tumor metastasis, due to its ability to regulate the presentation of fucosylated antigens on the cell surface.

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FUT4 antibody

May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Ver Producto