FGF23 antibody
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Name
FGF23 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab10478
Tested Applications
ELISA, WB
Description
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Fibroblast growth factor 23 (FGF23) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 28 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9GZV9 |
| Gene ID | 8074 |
| Alias | ADHR,FGFN,HYPF,HFTC2,HPDR2,PHPTC,Phosphatonin,Tumor-derived hypophosphatemia-inducing factor |
| Background | Antibody anti-FGF23 |
| Status | RUO |
| Note | Mol. Weight 28 kDa |
Background
FGF23 is a phosphaturic hormone primarily secreted by osteocytes and osteoblasts in bone tissue. It regulates phosphate homeostasis and vitamin D metabolism by reducing phosphate reabsorption in the kidneys and suppressing the synthesis of 1,25-dihydroxyvitamin D. FGF23 binds to its receptor in the presence of α-Klotho, promoting phosphate excretion to maintain serum phosphate levels. Elevated FGF23 levels are associated with chronic kidney disease (CKD), where impaired renal function leads to hyperphosphatemia and secondary hyperparathyroidism. Mutations in FGF23 can cause disorders like hypophosphatemic rickets and osteomalacia, characterized by bone mineralization defects. FGF23’s role in phosphate balance and bone health makes it a key target for managing CKD and related mineral metabolism disorders.
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