Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements(ERE) in an estrogen-dependent manner(PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Primary Antibodies
monoclonal
human,mouse
estrogen receptor 2(ER beta)
Mouse
IgG1
Unconjugated
liquid
ELISA, WB
50 kDa
≥95% as determined by SDS-PAGE
Protein A+G purification
WB: 1:500-1:2000
100µg
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
ESR2
Erb,ESRB,ODG8,ESTRB,NR3A2,ER-BETA,ESR-BETA,Estrogen receptor beta,Nuclear receptor subfamily 3 group A member 2
This product is for research use only.
Precio a consultar
Ver másThis gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors...
Precio a consultar
Ver másNuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter...
Precio a consultar
Ver más