ERK1/2 antibody
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935106861
info@markelab.com
name
ERK1/2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02846
tested applications
ELISA, WB, IHC, IF
Description
ERK1 and ERK2 belongs to the protein kinase superfamily. It is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. ERK1/2 catalized the reaction: ATP + a protein = ADP + a phosphoprotein. It is activated by tyrosine phosphorylation in response to insulin and NGF. This antibody can recognize both ERK1 and ERK2 with the molecular mass of 38-44 kDa.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | mitogen-activated protein kinase 1 (ERK1/2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:3000; IHC: 1:50-1:500; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 38-44 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P28482 |
| Gene ID | 5594 |
| Alias | Mitogen-activated protein kinase 1 (MAP kinase 1, MAPK 1),ERT1,Extracellular signal-regulated kinase 2 (ERK-2),MAP kinase isoform p42 (p42-MAPK),Mitogen-activated protein kinase 2 (MAP kinase 2, MAPK 2),MAPK1,ERK2,PRKM1,PRKM2 |
| Background | Antibody anti-ERK1/2 |
| Status | RUO |
| Note | Mol. Weight 38-44 kDa |
Descripción
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ERK1/2 antibody
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
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