EPCAM antibody

Este producto es parte de EPCAM - epithelial cell adhesion molecule
Product Graph
Contáctenos para saber el precio

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
EPCAM antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09783
tested applications
ELISA, WB, IHC

Description

Epithelial cell adhesion molecule(EpCAM, CD326) is a type I transmembrane glycoprotein that functions as a homophilic, epithelial-specific intercellular cell-adhesion molecule. In addition to cell adhesion, EpCAM is also involved in cellular signaling, cell migration, proliferation, and differentiation. EpCAM is highly expressed on most carcinomas and therefore of potential use as a diagnostic and prognostic marker for a variety of carcinomas, and has become a therapeutic target.(PMID: 20837599; 19249674; 21576002; 22647938)

Documents del producto

Instrucciones
Descargar
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
epithelial cell adhesion molecule (EPCAM)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 1:1000-1:10000; IHC: 1:50-1:500
Clonality
monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Clone ID
3C8
Observed MW
36 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Protein A+G purification
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P16422
Alias
ESA,KSA,M4S1,MK-1,DIAR5,EGP-2,EGP40,KS1/4,MIC18,TROP1,TACSTD1,Ep-CAM,Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen
Background
Antibody anti-EPCAM
Status
RUO
Note
Mol. Weight 36 kDa

Descripción

Epithelial Cell Adhesion Molecule (EPCAM) , also known as CD326 or TACSTD1 (tumor-associated calcium signal transducer 1), is a transmembrane glycoprotein prominently expressed on the surface of epithelial cells in various tissues. EpCAM plays a dual role in cellular adhesion and signaling, as well as in the regulation of cell proliferation and differentiation. Originally identified as a marker on cancer cells, EpCAM is also a vital component in normal epithelial physiology, where it participates in maintaining cell-cell adhesion and the structural integrity of epithelial layers. EpCAM has become a major focus in cancer research due to its high expression in numerous epithelial tumors, including colorectal, breast, lung, and ovarian cancers. It is frequently upregulated in cancer, where it contributes to cell proliferation, migration, and invasion, as well as tumor growth and metastasis. Its presence on circulating tumor cells has made EpCAM a promising biomarker for early cancer detection and prognosis. Beyond its role in oncogenesis, EpCAM is involved in regenerative processes in epithelial tissues, influencing stem cell behavior and tissue repair.

Related Products

APC-30140

APC Anti-Human CD326/EpCAM (9C4)

Ver Producto
EH3005

Human Ep-CAM/CD326 (Epithelial Cell Adhesion Molecule) ELISA Kit

Ver Producto
EM1005

Mouse EPCAM (Epithelial Cell Adhesion Molecule) ELISA Kit

Ver Producto