anti- DOCK7 antibody

Name: anti- DOCK7 antibody
Brand: FineTest
SKU: FNab02497
Availability: OnlineOnly

Este producto es parte de DOCK - Dedicator of Cytokinesis

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-DOCK7

proveedor

FineTest

reference

FNab02497

Tested Applications

ELISA, WB, IP

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Descripción

Functions as a guanine nucleotide exchange factor(GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization(PubMed:16982419). Has a role in pigmentation(By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells(RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3(By similarity).Multiple isoforms of DOCK 7 exist due to alternative splicing events. This DOCK 7 antibody can recognize all the isoforms.

Background

DOCK7 is a GEF for Rac1 and Cdc42, playing a key role in axon formation, neuronal polarization, and Schwann cell myelination. It regulates actin cytoskeleton dynamics and microtubule stabilization in neurons. DOCK7 interacts with the WAVE complex to promote Rac1-mediated actin remodeling, essential for neuronal growth and cortical development. It also regulates cell cycle progression in neural progenitors and is involved in epithelial-to-mesenchymal transition (EMT) in cancer. DOCK7 dysregulation is linked to neurological disorders and tumor progression. Mouse models with DOCK7 loss exhibit defects in neural development, including axonal growth and Schwann cell function.

Características del producto

clonality

polyclonal

reactivity

human,mouse,rat

immunogen target

dedicator of cytokinesis 7

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IP

observerd MW

240 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200-1:1000; IP: 1:500-1:1000

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

DOCK7

alias

dedicator of cytokinesis 7, DOCK7, KIAA1771, ZIR2

uniprot id

https://www.uniprot.org/uniprotkb/Q96N67

gene id

https://www.ncbi.nlm.nih.gov/gene/85440

note

This product is for research use only.

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