CYP4F3 antibody
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Description
Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid(20-HETE)(PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A(PubMed:11461919). Also converts eicosapentaenoate(EPA) to 20-hydroxyeicosapentaenoate(20-OH-EPA)(PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate(DHA) to 22-hydroxydocosahexaenoate(PubMed:16820285).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | cytochrome P450, family 4, subfamily F, polypeptide 3 (CYP4F3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 60 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q08477 |
| Gene ID | 4051 |
| Alias | Cytochrome P450 4F3,20-hydroxyeicosatetraenoic acid synthase (20-HETE synthase),CYPIVF3,Cytochrome P450-LTB-omega,Docosahexaenoic acid omega-hydroxylase CYP4F3,Leukotriene-B(4) 20-monooxygenase 2,Leukotriene-B(4) omega-hydroxylase 2,CYP4F3,LTB4H |
| Background | Antibody anti-CYP4F3 |
| Status | RUO |
| Note | Mol. Weight 60 kDa |
Descripción
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Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activity for arachidonic acid. Isoform CYP4F3B: Shows arachidonic acid omega-hydroxylase activity by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid(20-HETE)(PubMed:11461919, PubMed:16820285). Has a 30-fold higher Km for leukotriene-B(4) compared with CYP4F3A(PubMed:11461919). Also converts eicosapentaenoate(EPA) to 20-hydroxyeicosapentaenoate(20-OH-EPA)(PubMed:16820285). Acts as a polyunsaturated omega-3 fatty acids hydroxylase: mediates conversion of docosahexaenoate(DHA) to 22-hydroxydocosahexaenoate(PubMed:16820285).
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