Collagen Type IV antibody
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935106861
info@markelab.com
name
Collagen Type IV antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01844
tested applications
ELISA, IHC
Description
Type IV collagen is the major structural component of glomerular basement membranes(GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and-9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | collagen, type IV, alpha 2 (Collagen Type IV) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 200 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P08572 |
| Gene ID | 1284 |
| Alias | Collagen alpha-2(IV) chain,Canstatin,COL4A2 |
| Background | Antibody anti-COL4A2 |
| Status | RUO |
| Note | Mol. Weight 200 kDa |
Descripción
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