CIDEA antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
CIDEA antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab01710
Tested Applications
ELISA, WB
Description
Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter(By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | cell death-inducing DFFA-like effector a (CIDEA) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 25kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O60543 |
| Gene ID | 1149 |
| Alias | CIDE-A, cell death-inducing DFFA-like effector a, cell death inducing DFFA like effector a,CIDEA |
| Background | Antibody anti-CIDEA |
| Status | RUO |
| Note | Mol. Weight 25 kDa |
Background
CIDEA is a lipid droplet-associated protein involved in regulating lipid metabolism and energy homeostasis. It promotes lipid droplet fusion and inhibits lipolysis by modulating the activity of key enzymes such as adipose triglyceride lipase (ATGL). CIDEA is highly expressed in brown adipose tissue, where it contributes to thermogenesis and energy expenditure. Beyond its metabolic functions, CIDEA also plays a role in apoptosis, where it interacts with caspase-activated DNAse to mediate DNA fragmentation. Dysregulation of CIDEA is associated with obesity, insulin resistance, and non-alcoholic fatty liver disease. Research on CIDEA focuses on its dual roles in lipid metabolism and apoptosis, offering potential therapeutic targets for metabolic disorders and cancer.
Productos relacionados
Cell Death Activator CIDE-A (CIDEA) Antibody
CIDEA Antibody is a Rabbit Polyclonal Antibody against CIDEA.…
Ver producto
Cell Death Activator CIDE-A (CIDEA) Antibody
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of a…
Ver producto
Mouse Cell Death Inducing DFFA Like Effector A (CIDEA) Protein
Mouse Cell Death Inducing DFFA Like Effector A (CIDEA) is a recombinant Mouse protein expressed in E. coli.…
Ver producto