CD68 antibody
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935106861
info@markelab.com
name
CD68 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01492
tested applications
ELISA, IHC
Description
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue-and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD68 molecule (CD68) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | IHC: 1:500-1:2000 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Clone ID | 0F8 |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P34810 |
| Gene ID | 968 |
| Alias | GP110,LAMP4,SCARD1,Macrosialin |
| Background | Antibody anti-CD68 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
CD68 is a glycoprotein primarily expressed by cells of the monocyte/macrophage lineage. It belongs to the family of lysosomal-associated membrane proteins (LAMPs) and is widely used as a marker for macrophages, monocytes, dendritic cells, and other myeloid lineage cells. Although CD68 is predominantly associated with immune system cells, it is also found in some non-hematopoietic tissues and other cell types under certain conditions, such as fibroblasts and endothelial cells. This broad expression pattern supports its diverse role in cellular processes like phagocytosis, cell adhesion, and antigen presentation. CD68 is heavily involved in macrophage biology, specifically in processes like scavenging cellular debris, tissue remodeling, and immune surveillance. This protein plays a significant role in the clearance of pathogens and apoptotic cells, contributing to immune homeostasis. It is mainly located in lysosomes and endosomes, though it can also be present on the plasma membrane.
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