ITGA2B antibody
Contáctenos para saber el precio
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
ITGA2B antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab01478
Tested Applications
ELISA, WB, IHC
Description
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands(PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits(PMID: 17543136; 20029421).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | integrin, alpha 2b(platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:1000-1:10000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 125 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P08514 |
| Gene ID | 958 |
| Alias | GT,GT1,GTA,CD41,GP2B,HPA3,CD41B,GPIIb,BDPLT2,BDPLT16,PPP1R93,Integrin alpha-Iib,GPalpha IIb (GPIIb),Platelet membrane glycoprotein IIb |
| Background | Antibody anti-ITGA2B |
| Status | RUO |
| Note | Mol. Weight 125 kDa |
Background
ITGA2B, also known as integrin alpha 2b or CD41, is a transmembrane glycoprotein that plays a central role in platelet adhesion and aggregation. It is primarily expressed on platelets and megakaryocytes. Together with integrin beta 3 (ITGB3), ITGA2B forms the αIIbβ3 integrin complex (also known as GPIIb/IIIa), which is the most abundant integrin on the surface of platelets and is crucial for blood clot formation (hemostasis). This receptor mediates platelet aggregation by binding to fibrinogen, von Willebrand factor (vWF), fibronectin, and other adhesive proteins during platelet activation. When platelets are stimulated, the αIIbβ3 complex undergoes a conformational change that allows it to bind its ligands and mediate platelet-platelet interactions.
Productos relacionados
Integrin Alpha IIb / CD41 (ITGA2B) Antibody
ITGA2B encodes integrin alpha chain 2b.Integrins are heterodimeric integral membrane proteins composed of an alpha chain…
Ver producto
Integrin Alpha IIb / CD41 (ITGA2B) Antibody
ITGA2B encodes integrin alpha chain 2b.Integrins are heterodimeric integral membrane proteins composed of an alpha chain…
Ver producto
Integrin Alpha IIb / CD41 (ITGA2B) Antibody
Integrin Alpha 2B Antibody is a Rabbit Polyclonal against Integrin Alpha 2B.…
Ver producto