anti- CD247 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CD247 molecule |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 16 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, FC, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P20963 |
| Gene ID | 919 |
| Alias | T-cell surface glycoprotein CD3 zeta chain,T3Z,CD3H,CD3Q,CD3Z,TCRZ,IMD25,CD3ZETA,CD3-ZETA,T-cell receptor T3 zeta chain |
| Background | Antibody anti-CD247 |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
CD247 Molecule (CD247), also recognized as the T-cell receptor zeta chain (TCRζ), is an integral component of the T-cell receptor (TCR) complex, which plays a central role in T-cell activation and immune signaling. CD247 is primarily expressed on T lymphocytes, natural killer (NK) cells, and other immune cells and contributes to signal transduction during antigen recognition. It is characterized by its three immunoreceptor tyrosine-based activation motifs (ITAMs) within its intracellular domain, which become phosphorylated upon engagement of the TCR with peptide-MHC complexes. This phosphorylation event triggers downstream signaling cascades, ultimately leading to T-cell activation, proliferation, and cytokine production. CD247 is essential for the assembly, surface expression, and functional competence of the TCR-CD3 complex, and deficiencies or mutations in CD247 are associated with impaired immune responses, reduced TCR signaling, and susceptibility to infectious diseases or immune dysregulation. Aberrant CD247 expression has also been observed in various cancers, autoimmune disorders, and chronic infections, where it often correlates with T-cell exhaustion or dysfunction. Therapeutic approaches aimed at modulating CD247 function or restoring its expression hold promise for enhancing T-cell responses in immunotherapy, especially in cancer treatment and chronic viral infections. Furthermore, its role as a key molecule in immune checkpoint pathways has garnered attention for its potential as a target in the design of novel immune-boosting therapies.
Related Products
anti- CD247 antibody
Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Ver Producto
T-Cell Surface Glycoprotein CD3 Zeta Chain (CD247) Antibody
CD247 Antibody is a Rabbit Polyclonal antibody against CD247. The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Ver Producto
T-Cell Surface Glycoprotein CD3 Zeta Chain Phospho-Tyr142 (CD247 pY142) Antibody
Rabbit polyclonal antibody against CD3 zeta (CD247) protein phosphorylated at tyrosine 142 (Human) or tyrosine 143 (Mouse)
Ver Producto