CD206 antibody
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935106861
info@markelab.com
name
CD206 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01442
tested applications
ELISA, WB, IHC, FC
Description
CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains(responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia. This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | mannose receptor, C type 1 (CD206) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:2000; IHC: 1:50-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 166 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P22897 |
| Alias | Macrophage mannose receptor 1,MMR,hMR,CD206,MRC1L1,CLEC13D; CLEC13DL,C-type lectin domain family 13 member D,C-type lectin domain family 13 member D-like,Macrophage mannose receptor 1-like protein 1 |
| Background | Antibody anti-Mrc1 |
| Status | RUO |
| Note | Mol. Weight 166 kDa |
Descripción
MRC1, or mannose receptor C-type 1, is a type I transmembrane protein predominantly found on the surface of macrophages, dendritic cells, and certain endothelial cells. The receptor, encoded by the MRC1 gene, plays an essential role in immune surveillance and host defense against pathogens. It is a member of the C-type lectin receptor (CLR) family, a group of proteins involved in recognizing carbohydrate structures on pathogens, facilitating their capture, and subsequently initiating immune responses. The mannose receptor (MR) recognizes and binds to mannose, fucose, and N-acetylglucosamine residues, which are common on the surface of microorganisms, thereby enabling the immune system to detect a broad range of pathogens, including bacteria, fungi, and viruses. This recognition mechanism is crucial for identifying foreign pathogens that display distinct glycosylation patterns on their surfaces compared to host cells. Beyond its role in pathogen recognition, MRC1 is involved in various physiological processes, including antigen processing and presentation, phagocytosis, and homeostasis. By mediating endocytosis of specific ligands and facilitating the clearance of glycoproteins and degraded cell components, MRC1 supports tissue repair and cellular turnover, making it integral to both innate immunity and tissue remodeling.
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